The second (main) phase of an open, randomised, multicentre study to investigate the effectiveness of an intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT2)
Identifieur interne : 007146 ( Main/Exploration ); précédent : 007145; suivant : 007147The second (main) phase of an open, randomised, multicentre study to investigate the effectiveness of an intensive blood pressure reduction in acute cerebral haemorrhage trial (INTERACT2)
Auteurs : C. Delcourt [Australie] ; Y. Huang [République populaire de Chine] ; J. Wang [République populaire de Chine] ; E. Heeley [Australie] ; R. Lindley [Australie] ; C. Stapf [France] ; C. Tzourio [France] ; H. Arima [Australie] ; M. Parsons [Australie] ; J. Sun [République populaire de Chine] ; B. Neal [Australie] ; J. Chalmers [Australie] ; C. Anderson [Australie]Source :
- International Journal of Stroke [ 1747-4930 ] ; 2010-04.
Descripteurs français
- Wicri :
- topic : Protocole.
English descriptors
- KwdEn :
- Absolute difference, Active treatment, Acute intracerebral hemorrhage, Acute stroke, American heart association, April, Blood pressure, Blood treatment, Christophe tzourio, Clear evidence, Clinical outcome, Clinical practice, Clinical research unit, Clinical trial, Clinical trial protocols, Control group, Craig anderson, Deep coma, Definite indication, Delcourt, Dependency, European stroke organization, Exclusion criteria, George institute, Glasgow coma scale, Haematoma, Haematoma expansion, Haematoma growth, Haemorrhage, Haemorrhage trial, Health stroke scale, High likelihood, High rates, Hospital discharge, Imaging technology, Intensive blood pressure reduction, Intensive care unit, Intensive group, Intensive regimen, Interact2, Interact2 study, International health, Intracerebral, Intracerebral haemorrhage, Jiguang wang, Journal compilation, Lancet neurol, Lariboisiere hospital, Mmhg, More cases, Oral antihypertensive therapy, Outcome assessments, Physical function, Pilot phase, Pilot study, Poor outcome, Primary outcome, Protocol, Randomisation, Randomised, Rankin scale, Recurrent stroke, Relative reduction, Relative risk reduction, Responsible physician, Royal prince alfred hospital, Sample size, Secondary outcomes, Spontaneous intracerebral haemorrhage, Spontaneous intracerebral hemorrhage, Stroke, Structural abnormality, Surgical evacuation, Systematic review, Systolic, Systolic blood pressure, Target systolic, Telephone interview, Treatment effect, Treatment groups, World stroke organization, Yining huang.
- Teeft :
- Absolute difference, Active treatment, Acute intracerebral hemorrhage, Acute stroke, American heart association, April, Blood pressure, Blood treatment, Christophe tzourio, Clear evidence, Clinical outcome, Clinical practice, Clinical research unit, Clinical trial, Clinical trial protocols, Control group, Craig anderson, Deep coma, Definite indication, Delcourt, Dependency, European stroke organization, Exclusion criteria, George institute, Glasgow coma scale, Haematoma, Haematoma expansion, Haematoma growth, Haemorrhage, Haemorrhage trial, Health stroke scale, High likelihood, High rates, Hospital discharge, Imaging technology, Intensive blood pressure reduction, Intensive care unit, Intensive group, Intensive regimen, Interact2, Interact2 study, International health, Intracerebral, Intracerebral haemorrhage, Jiguang wang, Journal compilation, Lancet neurol, Lariboisiere hospital, Mmhg, More cases, Oral antihypertensive therapy, Outcome assessments, Physical function, Pilot phase, Pilot study, Poor outcome, Primary outcome, Protocol, Randomisation, Randomised, Rankin scale, Recurrent stroke, Relative reduction, Relative risk reduction, Responsible physician, Royal prince alfred hospital, Sample size, Secondary outcomes, Spontaneous intracerebral haemorrhage, Spontaneous intracerebral hemorrhage, Stroke, Structural abnormality, Surgical evacuation, Systematic review, Systolic, Systolic blood pressure, Target systolic, Telephone interview, Treatment effect, Treatment groups, World stroke organization, Yining huang.
Abstract
Rationale: The INTERACT pilot study demonstrated the feasibility of the protocol, safety of early intensive blood pressure lowering and effects on haematoma expansion within 6 h of onset of intracerebral haemorrhage. This article describes the design of the second, main phase, INTERACT2.
Url:
DOI: 10.1111/j.1747-4949.2010.00415.x
Affiliations:
- Australie, France, République populaire de Chine
- Nouvelle-Galles du Sud, Île-de-France
- Paris, Pékin, Sydney
- Université de Sydney
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Le document en format XML
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Wang</name><affiliation wicri:level="1"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Institute of Hypertension, Rui Jin Hospital, Shanghai Jiaotong University, Shanghai</wicri:regionArea><wicri:noRegion>Shanghai</wicri:noRegion></affiliation></author><author><name sortKey="Heeley, E" sort="Heeley, E" uniqKey="Heeley E" first="E." last="Heeley">E. Heeley</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for International Health, Royal Prince Alfred Hospital, University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Lindley, R" sort="Lindley, R" uniqKey="Lindley R" first="R." last="Lindley">R. Lindley</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>Sydney Medical School – Western, University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Stapf, C" sort="Stapf, C" uniqKey="Stapf C" first="C." last="Stapf">C. Stapf</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>Department of Neurology, European Regional Coordinating Centre, Clinical Research Unit, Lariboisière Hospital, APHP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 708, APHP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Tzourio, C" sort="Tzourio, C" uniqKey="Tzourio C" first="C." last="Tzourio">C. Tzourio</name><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 708, APHP, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Arima, H" sort="Arima, H" uniqKey="Arima H" first="H." last="Arima">H. Arima</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for International Health, Royal Prince Alfred Hospital, University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Parsons, M" sort="Parsons, M" uniqKey="Parsons M" first="M." last="Parsons">M. Parsons</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>John Hunter Hospital, Hunter Medical Research Institute, University of Newcastle, New Lambton, NSW</wicri:regionArea><wicri:noRegion>NSW</wicri:noRegion></affiliation></author><author><name sortKey="Sun, J" sort="Sun, J" uniqKey="Sun J" first="J." last="Sun">J. Sun</name><affiliation wicri:level="3"><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>The George Institute, Beijing</wicri:regionArea><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Neal, B" sort="Neal, B" uniqKey="Neal B" first="B." last="Neal">B. Neal</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for International Health, Royal Prince Alfred Hospital, University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for International Health, Royal Prince Alfred Hospital, University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Anderson, C" sort="Anderson, C" uniqKey="Anderson C" first="C." last="Anderson">C. Anderson</name><affiliation wicri:level="4"><country xml:lang="fr">Australie</country><wicri:regionArea>The George Institute for International Health, Royal Prince Alfred Hospital, University of Sydney, Sydney, NSW</wicri:regionArea><orgName type="university">Université de Sydney</orgName><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Australie</country></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">International Journal of Stroke</title><title level="j" type="alt">INTERNATIONAL JOURNAL OF STROKE</title><idno type="ISSN">1747-4930</idno><idno type="eISSN">1747-4949</idno><imprint><biblScope unit="vol">5</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="110">110</biblScope><biblScope unit="page" to="116">116</biblScope><biblScope unit="page-count">7</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-04">2010-04</date></imprint><idno type="ISSN">1747-4930</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1747-4930</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Absolute difference</term><term>Active treatment</term><term>Acute intracerebral hemorrhage</term><term>Acute stroke</term><term>American heart association</term><term>April</term><term>Blood pressure</term><term>Blood treatment</term><term>Christophe tzourio</term><term>Clear evidence</term><term>Clinical outcome</term><term>Clinical practice</term><term>Clinical research unit</term><term>Clinical trial</term><term>Clinical trial protocols</term><term>Control group</term><term>Craig anderson</term><term>Deep coma</term><term>Definite indication</term><term>Delcourt</term><term>Dependency</term><term>European stroke organization</term><term>Exclusion criteria</term><term>George institute</term><term>Glasgow coma scale</term><term>Haematoma</term><term>Haematoma expansion</term><term>Haematoma growth</term><term>Haemorrhage</term><term>Haemorrhage trial</term><term>Health stroke scale</term><term>High likelihood</term><term>High rates</term><term>Hospital discharge</term><term>Imaging technology</term><term>Intensive blood pressure reduction</term><term>Intensive care unit</term><term>Intensive group</term><term>Intensive regimen</term><term>Interact2</term><term>Interact2 study</term><term>International health</term><term>Intracerebral</term><term>Intracerebral haemorrhage</term><term>Jiguang wang</term><term>Journal compilation</term><term>Lancet neurol</term><term>Lariboisiere hospital</term><term>Mmhg</term><term>More cases</term><term>Oral antihypertensive therapy</term><term>Outcome assessments</term><term>Physical function</term><term>Pilot phase</term><term>Pilot study</term><term>Poor outcome</term><term>Primary outcome</term><term>Protocol</term><term>Randomisation</term><term>Randomised</term><term>Rankin scale</term><term>Recurrent stroke</term><term>Relative reduction</term><term>Relative risk reduction</term><term>Responsible physician</term><term>Royal prince alfred hospital</term><term>Sample size</term><term>Secondary outcomes</term><term>Spontaneous intracerebral haemorrhage</term><term>Spontaneous intracerebral hemorrhage</term><term>Stroke</term><term>Structural abnormality</term><term>Surgical evacuation</term><term>Systematic review</term><term>Systolic</term><term>Systolic blood pressure</term><term>Target systolic</term><term>Telephone interview</term><term>Treatment effect</term><term>Treatment groups</term><term>World stroke organization</term><term>Yining huang</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Absolute difference</term><term>Active treatment</term><term>Acute intracerebral hemorrhage</term><term>Acute stroke</term><term>American heart association</term><term>April</term><term>Blood pressure</term><term>Blood treatment</term><term>Christophe tzourio</term><term>Clear evidence</term><term>Clinical outcome</term><term>Clinical practice</term><term>Clinical research unit</term><term>Clinical trial</term><term>Clinical trial protocols</term><term>Control group</term><term>Craig anderson</term><term>Deep coma</term><term>Definite indication</term><term>Delcourt</term><term>Dependency</term><term>European stroke organization</term><term>Exclusion criteria</term><term>George institute</term><term>Glasgow coma scale</term><term>Haematoma</term><term>Haematoma expansion</term><term>Haematoma growth</term><term>Haemorrhage</term><term>Haemorrhage trial</term><term>Health stroke scale</term><term>High likelihood</term><term>High rates</term><term>Hospital discharge</term><term>Imaging technology</term><term>Intensive blood pressure reduction</term><term>Intensive care unit</term><term>Intensive group</term><term>Intensive regimen</term><term>Interact2</term><term>Interact2 study</term><term>International health</term><term>Intracerebral</term><term>Intracerebral haemorrhage</term><term>Jiguang wang</term><term>Journal compilation</term><term>Lancet neurol</term><term>Lariboisiere hospital</term><term>Mmhg</term><term>More cases</term><term>Oral antihypertensive therapy</term><term>Outcome assessments</term><term>Physical function</term><term>Pilot phase</term><term>Pilot study</term><term>Poor outcome</term><term>Primary outcome</term><term>Protocol</term><term>Randomisation</term><term>Randomised</term><term>Rankin scale</term><term>Recurrent stroke</term><term>Relative reduction</term><term>Relative risk reduction</term><term>Responsible physician</term><term>Royal prince alfred hospital</term><term>Sample size</term><term>Secondary outcomes</term><term>Spontaneous intracerebral haemorrhage</term><term>Spontaneous intracerebral hemorrhage</term><term>Stroke</term><term>Structural abnormality</term><term>Surgical evacuation</term><term>Systematic review</term><term>Systolic</term><term>Systolic blood pressure</term><term>Target systolic</term><term>Telephone interview</term><term>Treatment effect</term><term>Treatment groups</term><term>World stroke organization</term><term>Yining huang</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Protocole</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Rationale: The INTERACT pilot study demonstrated the feasibility of the protocol, safety of early intensive blood pressure lowering and effects on haematoma expansion within 6 h of onset of intracerebral haemorrhage. This article describes the design of the second, main phase, INTERACT2.</div></front></TEI><affiliations><list><country><li>Australie</li><li>France</li><li>République populaire de Chine</li></country><region><li>Nouvelle-Galles du Sud</li><li>Île-de-France</li></region><settlement><li>Paris</li><li>Pékin</li><li>Sydney</li></settlement><orgName><li>Université de Sydney</li></orgName></list><tree><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Delcourt, C" sort="Delcourt, C" uniqKey="Delcourt C" first="C." last="Delcourt">C. Delcourt</name></region><name sortKey="Anderson, C" sort="Anderson, C" uniqKey="Anderson C" first="C." last="Anderson">C. Anderson</name><name sortKey="Anderson, C" sort="Anderson, C" uniqKey="Anderson C" first="C." last="Anderson">C. Anderson</name><name sortKey="Arima, H" sort="Arima, H" uniqKey="Arima H" first="H." last="Arima">H. Arima</name><name sortKey="Chalmers, J" sort="Chalmers, J" uniqKey="Chalmers J" first="J." last="Chalmers">J. Chalmers</name><name sortKey="Heeley, E" sort="Heeley, E" uniqKey="Heeley E" first="E." last="Heeley">E. Heeley</name><name sortKey="Lindley, R" sort="Lindley, R" uniqKey="Lindley R" first="R." last="Lindley">R. Lindley</name><name sortKey="Neal, B" sort="Neal, B" uniqKey="Neal B" first="B." last="Neal">B. Neal</name><name sortKey="Parsons, M" sort="Parsons, M" uniqKey="Parsons M" first="M." last="Parsons">M. Parsons</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Huang, Y" sort="Huang, Y" uniqKey="Huang Y" first="Y." last="Huang">Y. Huang</name></noRegion><name sortKey="Sun, J" sort="Sun, J" uniqKey="Sun J" first="J." last="Sun">J. Sun</name><name sortKey="Wang, J" sort="Wang, J" uniqKey="Wang J" first="J." last="Wang">J. Wang</name></country><country name="France"><region name="Île-de-France"><name sortKey="Stapf, C" sort="Stapf, C" uniqKey="Stapf C" first="C." last="Stapf">C. Stapf</name></region><name sortKey="Stapf, C" sort="Stapf, C" uniqKey="Stapf C" first="C." last="Stapf">C. Stapf</name><name sortKey="Tzourio, C" sort="Tzourio, C" uniqKey="Tzourio C" first="C." last="Tzourio">C. Tzourio</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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